The Lamb Center for Pediatric Research is an interdisciplinary research unit combining interests in infectious diseases, microbiology, and immunology. The Center, established in 1990 through the generous support of Mr. and Mrs. George C. Lamb, Jr., is dedicated to basic research in the molecular pathogenesis of pediatric infectious diseases. Lamb Center investigators study how viruses target distinct tissues in the infected host, enter into host cells, reprogram the cellular environment to allow viral replication, and antagonize host defense mechanisms to cause disease. A current thrust of Lamb Center efforts is to use model viruses as platforms to develop new viral vaccines and virus-based therapeutics. See below to learn more about our investigators.
The Dermody laboratory uses the mammalian reoviruses as an experimental system to study mechanisms by which viruses cause cell death and disease. Using a multidisciplinary approach, the lab investigates mechanisms of reovirus attachment, cell entry, genome replication, and apoptosis. These studies will provide a comprehensive analysis of the steps in reovirus replication that culminate in disease. Learn more about Dr. Dermody's research.
Much of the laboratory effort is focused on studies of viral and cellular proteins that regulate reovirus replication with the goal to understand how functional domains, biochemical activities, and structural motifs within these molecules coordinate discrete steps of the viral infectious cycle and influence viral pathology in the animal host. Learn more about Dr. Chappell's research.
The Denison Lab studies the coronaviruses, a family of plus-strand RNA viruses that cause important infections in many animals and colds in humans. Dr. Denison's laboratory has focused on the replication and cell biology of a mouse coronavirus, murine hepatitis virus (MHV), which is a model for studying SARS-CoV and other coronaviruses. Learn more about Dr. Denison's research.
Dr. Wilson's laboratory has two main areas of study. The first is to understand how non-enveloped viruses are uncoated (or disassembled) using mammalian reoviruses as a model system. The second is to develop reovirus as an oral vaccine to prevent HIV infection using the reovirus reverse genetics system. Learn more about Dr. Wilson's research.