Mildred Stahlman Division of Neonatology
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Bibhash C. Paria, Ph.D.
Jorn-Hendrik Weitkamp, M.D.
Elaine L. Shelton Lab
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Weitkamp, Jorn-Hendrik, M.D.

Research Description  
In collaboration with the Departments of Pediatric Surgery, Pathology and Biomedical Engineering, we developed novel tools that permit the study of the development and function of critical immune effector and suppressor cells in the premature intestine.  Our methods include the analysis of human intestinal immune cells isolated from surgically resected tissue specimens by multicolor and mass flow cytometry and multitrap nanophysiometer microfluidic devices as well as mechanistic animal models. We use modern sequencing technology and mass spectometry to dissect the role of the mucosal microbiome and of breast milk components on immune development in the premature intestine. We are currently exploring molecular mechanisms for priming of the premature intestine towards a hyperinflammatory response and increased susceptibility for NEC.

Our research is supported by the Vanderbilt Digestive Disease Research Center, the Vanderbilt Institute for Clinical and Translational Research, the American Academy of Pediatrics and the National Institute of Health.

Clinical Interests
Neonatal infectious diseases and immunology
Necrotizing enterocolitis  

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